From Tendon Injury to Collagen-based Tendon Regeneration: Overview and Recent Advances
نویسندگان
چکیده
منابع مشابه
Synthetic collagen fascicles for the regeneration of tendon tissue.
The structure of an ideal scaffold for tendon regeneration must be designed to provide a mechanical, structural and chemotactic microenvironment for native cellular activity to synthesize functional (i.e. load bearing) tissue. Collagen fibre scaffolds for this application have shown some promise to date, although the microstructural control required to mimic the native tendon environment has ye...
متن کاملCell- and gene-based approaches to tendon regeneration.
Repair of rotator cuff tears in experimental models has been significantly improved by the use of enhanced biologic approaches, including platelet-rich plasma, bone marrow aspirate, growth factor supplements, and cell- and gene-modified cell therapy. Despite added complexity, cell-based therapies form an important part of enhanced repair, and combinations of carrier vehicles, growth factors, an...
متن کاملRecent advances in the reconstruction of complex Achilles tendon defects.
Large, complex lower-extremity defects in the region of the Achilles tendon occur when tendon loss or disruption is complicated by damage to surrounding structures, including soft tissue, vessels, or bone. The surgical approach to these complex defects has evolved from simple amputation to the recognition that satisfactory reconstruction has three components: functional reconstruction of the te...
متن کاملIntroduction to Equine Tendon Injury
Equine tendon injuries have been recognized and treated for centuries. In early American texts, poor conformation was considered a primary risk factor. “Tied-in” at the knees and long, weak, and slender pasterns were thought to predispose the horse to injury because of mechanical disadvantage. Any trait that favored fetlock extension such as low heels and long toes was thought to increase a hor...
متن کاملTendon and Ligament Injury
The most frequently injured tendons and ligaments in the horse are those on the palmar or plantar aspect of the distal limb. For this reason, this series of presentations will focus on these injuries. Diagnosis of strain-induced tendon injuries of the equine distal limb are based on history (usually a preceding period of exercise) and the development of the signs of inflammation (pain, heat, sw...
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ژورنال
عنوان ژورنال: Current Pharmaceutical Design
سال: 2017
ISSN: 1381-6128
DOI: 10.2174/1381612823666170516130515